Thermal Fuse When subjects are asked to perceptually bind rapidly alternating colour and motion stimuli, the pairings they report are different from the ones actually occurring in physical reality.A possible explanation for this misbinding is that the time necessary for perception is different for different visual attributes.Such an explanation is
Acetic Acid as Processing Aid Dramatically Improves Organic Solvent Solubility of Weakly Basic Drugs for Spray Dried Dispersion Manufacture
Many active pharmaceutical ingredients (APIs) in the pharmaceutical pipeline require bioavailability enhancing formulations due to very low aqueous solubility.Although spray dried dispersions (SDDs) have demonstrated broad utility in enhancing the bioavailability of such APIs by trapping them in a high-energy amorphous form, many new chemical entit
Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model
Abstract Background Platelet dysfunction importantly contributes to trauma-induced coagulopathy (TIC).Our aim was to examine the impact of transfusing platelets (PLTs) in a 2:1 PLT-to-red blood cell (RBC) ratio versus the standard 1:1 ratio on transfusion requirements, correction of TIC, and organ damage in a rat multiple trauma transfusion model.M
Influencing Factors of Artificial Snow Particle Size under Natural Environmental Conditions
In this study, artificial snow is produced under natural conditions using a snowmaking machine, and the microscopic morphology of the snow crystals is obtained.The sizes of snow particles and the factors that influence them under various working conditions are subsequently analyzed, and the formation of artificial snow is deduced.The results show t
Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein
Abstract Intracellular retrograde transport in eukaryotic cells relies exclusively on the molecular motor cytoplasmic dynein 1.Unlike its counterpart, kinesin, dynein has a single isoform, which raises questions about its cargo specificity and regulatory mechanisms.The precision of dynein-mediated cargo transport is governed by a multitude of facto